UMC Mainz
Unit "Responses to DNA Lesions" (AK Khobta) 
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  Publications of AK Khobta
  • Allgayer, J., Kitsera, N., Bartelt, S., Epe, B., Khobta, A. Nucleotide excision repair of abasic DNA lesions. Nucleic Acids Res, gkz558 [Epub ahead of print] (highly read)
 full text via the publisher's site (open access)
  • Kitsera, N., Allgayer, J., Parsa, E., Geier, N., Rossa, M., Carell, T., Khobta, A. Functional impacts of 5-hydroxymethylcytosine,
    5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter. 
    Nucleic Acids Res, 45, 11033-11042 (highly cited) 
 full text via the publisher's site (open access)
  • Allgayer, J., Kitsera, N., Bartelt, S., Epe, B., Khobta, A. Widespread transcriptional gene inactivation by a repair intermediate of 8-oxoguanine. Nucleic Acids Res, 44, 7267-7280 (highly cited)
full text via the publisher's site (open access)

  • Krieg, B., Hirsch, M., Scholz, E., Nuhn, L., Tabujew, I., Bauer, H., Decker, S., Khobta, A., et al. New techniques to assess in vitro release of siRNA from nanoscale polyplexes. Pharm Res, 32, 1957-1974
 full text via the publisher's site


  • Lühnsdorf, B., Epe, B., Khobta, A. Excision of uracil from transcribed DNA negatively affects the gene expression. J Biol Chem, 289, 22008-22018 
full text via the publisher's site (free access)

  • Kitsera, N., Gasteiger, K., Lühnsdorf, B., Allgayer, J., Epe B., Carell, T., Khobta, A. Cockayne syndrome: varied requirement of transcription-coupled nucleotide excision repair for the removal of three structurally different adducts from transcribed DNA. PLoS One, 9, e94405 (highly recommended)
full text via the publisher's site (open access)


  • Allgayer, J., Kitsera, N., von der Lippen, C., Epe B., Khobta, A. Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence. Nucleic Acids Res., 41, 8559-8571
full text via the publisher's site (open access)

  • Keuser, B., Khobta, A., Galle, K., Anderhub, S., Schulz, I., Pauly, K., Epe B. Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction. Mutagenesis, 28, 569-576 
full text via the publisher's site (free access)

  • Khobta, A., Epe, B. Repair of oxidatively generated DNA damage in Cockayne syndrome. Mech. Ageing Dev., 134, 253-260 
 full text via the publisher's site


  • Lühnsdorf, B., Kitsera N., Warken, D., Lingg, T., Epe B., Khobta, A. Generation of reporter plasmids containing defined base modifications in the DNA strand of choice. Anal. Biochem., 425, 47-53
 full text via the publisher's site

  • Khobta, A., Epe, B. (2012) Interactions between DNA damage, repair, and transcription. Mutat Res., 736, 5-14 
 full text via the publisher's site

  • Kitsera N., Stathis, D., Lühnsdorf, B., Müller, H., Carell, T., Epe B., Khobta, A. 8-oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription but is converted into transcription-blocking damage by OGG1. Nucleic Acids Res., 39, 5926-5934 (highly cited)
full text via the publisher's site (open access)

  • Fusser, M., Nesse, G., Khobta, A., Xia, N., Li, H., Klungland, A., Epe B. Spontaneous mutagenesis in Csbm/mOgg1-/- mice is attenuated by dietary resveratrol. Carcinogenesis,32, 80-85 
full text via the publisher's site (free access)


  • Khobta, A., Anderhub, S., Kitsera, N., Epe, B. Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. Nucleic Acids Res., 38, 4285-4295
full text via the publisher's site (open access)

  • Khobta, A., Lingg, T., Schulz, I., Warken, D., Kitsera, N., Epe, B. Mouse Csb protein is important for gene expression in the presence of a single-strand break in the non-transcribed DNA strand. DNA Repair, 9, 985-993 
 full text via the publisher's site

2009 and earlier

  • Khobta, A., Kitsera, N., Speckmann, B., Epe, B. (2009) 8-Oxoguanine DNA glycosylase (Ogg1) causes a transcriptional inactivation of damaged DNA in the absence of functional Cockayne syndrome B (Csb) protein. DNA Repair, 8, 309-317 (highly cited)
  • Kitsera, N., Khobta, A., and Epe, B. (2007) Destabilized green fluorescent protein detects rapid removal of transcription blocks after genotoxic exposure. Biotechniques, 43, 222-227
  • Bockamp, E., Christel, C., Hameyer, D., Khobta, A., Maringer, M., Reis, M., Heck, R., Cabezas-Wallscheid, N., Epe, B., Oesch-Bartolomowicz, B., Kaina, B., Schmitt, S., Eshkind, L. (2007) Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system. J. Gene Med., 9, 308-318 
  • Khobta, A., Ferri, F., Lotito, L., Montecucco, A., Rossi, R., Capranico, G. (2006) Early Effects of Topoisomerase I Inhibition on RNA Polymerase II Along Transcribed Genes in Human Cells. J. Mol. Biol., 357, 127-138 (highly cited)
  • Tonelli,R., Sartini, R., Fronza, R., Freccero, F., Franzoni, M., Dongiovanni, D., Ballarini, M., Ferrari, S., D’Appolito, M., Di Cola, G, Capranico, G., Khobta, A., Campanini, R, Paolucci, P., Minucci, S., Pession, A. (2006) G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloidleukemia cells is p21 dependent and MLL-AF9 independent. Leukemia, 20, 1307-1310 
  • Khobta, A., Carlo-Stella, C., Capranico, G. (2004) Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. Cancer Res., 64, 2656-2662
  • Alessandri, M., Beretta, G.L., Ferretti, E., Mancia, A., Khobta, A., Capranico, G. (2004) Enhanced CPT sensitivity of yeast cells and selective relaxation of Gal4 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins. J. Mol. Biol., 337, 295-305 
  • Hobta, A., Lisovskiy, I., Mikhalap, S., Kolybo, D., Romanyuk, S., Soldatkina, M., Markeyeva, N., Garmanchouk, L., Sidorenko, S.P., Pogrebnoy, P.V. (2001) Epidermoid Carcinoma derived Antimicrobial Peptide (ECAP) inhibits phosphorylation by the protein kinases in vitro. Cell Biochem. Funct., 19, 291-298 
  • Pogrebnoy, P.V., Hobta, A.I., Soldatkina, M.A., Garmanchouk, L.V., Markeeva, N.V., Eremenko, T. (1998) A protein kinase inhibitor from A431 subline overexpressing TGF alpha possesses antimicrobial activity. New Microbiol., 21, 269-273 

all publications (PubMed)

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Andriy Khobta (CV)
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Last modified 30 June, 2017 

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